Suzuki-type Pd(0) coupling reactions in the synthesis of 2-arylpurines as Cdk inhibitors

Lucie Vandromme; Sandrine Piguel; Olivier Lozach; Laurent Meijer; Michel Legraverend; David S Grierson

doi:10.1016/j.bmcl.2006.03.060

Suzuki-type Pd(0) coupling reactions in the synthesis of 2-arylpurines as Cdk inhibitors

Bioorg Med Chem Lett. 2006 Jun 15;16(12):3144-6. doi: 10.1016/j.bmcl.2006.03.060. Epub 2006 Apr 17.

Authors

Lucie Vandromme¹, Sandrine Piguel, Olivier Lozach, Laurent Meijer, Michel Legraverend, David S Grierson

Affiliation

¹ UMR 176 CNRS-Institut Curie, Institut Curie Section de Recherche, Bât. 110, Centre Universitaire, 91405 Orsay, France.

PMID: 16616489
DOI: 10.1016/j.bmcl.2006.03.060

Abstract

A new series of 2-aryl-substituted purine derivatives has been synthesized by Suzuki Pd(0) coupling reactions. Moderate in vitro inhibitory activity against Cdk1 and Cdk5 was observed. These compounds are inactive against GSK3.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

CDC2 Protein Kinase / antagonists & inhibitors*
CDC2 Protein Kinase / metabolism
Cyclin-Dependent Kinase 5 / antagonists & inhibitors*
Cyclin-Dependent Kinase 5 / metabolism
Glycogen Synthase Kinase 3 / antagonists & inhibitors
Glycogen Synthase Kinase 3 / metabolism
Molecular Structure
Protein Kinase Inhibitors / chemical synthesis*
Protein Kinase Inhibitors / chemistry
Protein Kinase Inhibitors / pharmacology*
Purines / chemical synthesis
Purines / chemistry*
Purines / pharmacology*

Substances

Protein Kinase Inhibitors
Purines
Cyclin-Dependent Kinase 5
CDC2 Protein Kinase
Glycogen Synthase Kinase 3
purine